Evaluation of the Effect of a New Microemulsion Based Hydrogel on Partial Thickness Burn Wound in Rat and its Comparison with Local Effects of Gauze Dressing
Background: Hydrogel dressings, including those with features, are suitable for use in wound coatings, especially burn wounds. Sesame oil is a natural abundant composition in nature, which can be used in the preparation of hydrogels. The aim of this study was to evaluate the effect of hydrogel (sesame oil microemulsion based), in healing burns of half thickness and it’s comparison with the local effects of gauze dressing alone.
Materials & Methods: In this animal study 21 male rats were randomly divided into 3 groups. After producing half-thickness burns of the size 8 × 5 cm on the back of all the rats, in the first group of rats used the sesame oil microemulsion based hydrogel for dressing, in the second group used gauze dressing alone and third group (control group) was without dressing. On days 7th and 14th all rats had digital photography, as well as random a number of rats in each group were cultured and biopsied. The wounds were examined and evaluated by the Image J. software partitioning samples were taken for histopathology.
Results: The findings of this study showed that the Average wound surface in sesame oil microemulsion based hydrogel group at the end of the fourteenth day was 1.58 ± 1.17 cm2 and gauze dressing was 6.62 ± 0.55 cm2, and in the control group was 8.94 ± 1.54cm2. According to our results, there is a significant difference about the rate of wound healing in group of microemulsion based hydrogel to the other groups (P<0.001).
Discussion & Conclusions: sesame oil microemulsion based hydrogel to quickly restore the proper, recommended as a suitable dressing.
